Data/hora: 14/05/2024 04:35:36

Biblioteca(s): 	Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios.	
Data corrente: 	17/11/2023	
Data da última atualização: 	23/01/2024	
Autoria: 	SANTOS, A. T. L. dos; CARNEIRO, J. N. P.; CRUZ, R. P. da; SALES, D. L.; PINHEIRO, J. C. A.; FREITAS, M. A. de; KERNTOPF, M. R.; DELMONDES, G. de A.; RIBEIRO, P. R. V.; BRITO, E. S. de; BATISTA, F. L. A.; MAGALHÃES, F. E. A.; PITA NETO, I. C.; BRAGA, M. F. B. M.; KOWALSKI, R.; KOWALSKA, G.; SZOPA, A.; BAJ, T.; COUTINHO, H. D. M.	
Afiliação: 	ANTONIA THASSYA LUCAS DOS SANTOS, UNIVERSIDADE REGIONAL DO CARIRI; JOARA NÁLYDA PEREIRA CARNEIRO, UNIVERSIDADE REGIONAL DO CARIRI; RAFAEL PEREIRA DA CRUZ, UNIVERSIDADE REGIONAL DO CARIRI; DÉBORA LIMA SALES, UNIVERSIDADE REGIONAL DO CARIRI; JACQUELINE COSMO ANDRADE-PINHEIRO, UNIVERSIDADE REGIONAL DO CARIRI; MARIA AUDILENE DE FREITAS, UNIVERSIDADE FEDERAL DE PERNAMBUCO; MARTA REGINA KERNTOPF, UNIVERSIDADE REGIONAL DO CARIRI; GYLLYANDESON DE ARAÚJO DELMONDES, UNIVERSIDADE REGIONAL DO CARIRI; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; EDY SOUSA DE BRITO, CNAT; FRANCISCO LUCAS ALVES BATISTA, UNIVERSIDADE REGIONAL DO CARIRI; FRANCISCO ERNANI ALVES MAGALHÃES, UNIVERSIDADE ESTADUAL DO CEARÁ; IVO CAVALCANTE PITA NETO, FACULDADE CECAPE; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, UNIVERSIDADE REGIONAL DO CARIRI; RADOSŁAW KOWALSKI, UNIWERSYTET PRZYRODNICZNY W LUBLINIE; GRAZYNA KOWALSKA, UNIWERSYTET PRZYRODNICZNY W LUBLINIE; ALEKSANDRA SZOPA, UNIWERSYTET MEDYCZNY W LUBLINIE; TOMASZ BAJ, UNIWERSYTET MEDYCZNY W LUBLINIE; HENRIQUE DOUGLAS MELO COUTINHO, UNIVERSIDADE REGIONAL DO CARIRI.	
Título: 	UPLC-MS-ESI-QTOF analysis and antifungal activity of aqueous extracts of Spondias tuberosa.	
Ano de publicação: 	2023	
Fonte/Imprenta: 	Molecules, Basel, v. 28, n. 1, art. 305, Jan. 2023.	
Páginas: 	14 p.	
DOI: 	https://doi.org/10.3390/molecules28010305	
Idioma: 	Inglês	
Conteúdo: 	This study aimed to identify the chemical composition of the Spondias tuberosa aqueous leaf and root extracts (EALST and EARST) and to evaluate their effect, comparatively, against opportunistic pathogenic fungi. Ultra-Performance Liquid Chromatography Coupled to a Quadrupole/Time of Flight System (UPLC-MS-ESI-QTOF) was employed for chemical analysis. Candida albicans and C. tropicalis standard strains and clinical isolates were used (CA INCQS 40006, CT INCQS 40042, CA URM 5974, and CT URM 4262). The 50% Inhibitory Concentration for the fungal population (IC50) was determined for both the intrinsic action of the extracts and the extract/fluconazole (FCZ) associations. The determination of the Minimum Fungicidal Concentration (MFC) and the verification of effects over fungal morphological transitions were performed by subculture in Petri dishes and humid chambers, respectively, both based on micro-dilution. UPLC-MS-ESI-QTOF analysis revealed the presence of phenolic and flavonoid compounds. The association of the extracts with fluconazole, resulted in IC50 values from 2.62 µg/mL to 308.96 µg/mL. The MFC of the extracts was ?16,384 µg/mL for all tested strains, while fluconazole obtained an MFC of 8192 µg/mL against C. albicans strains. A reduction in MFC against CA URM 5974 (EALST: 2048 µg/mL and EARST: 1024 µg/mL) occurred in the extract/fluconazole association.	
Palavras-Chave: 	Popular medicine.	
Thesagro: 	Cromatografia; Spondias Tuberosa; Umbu.	
Thesaurus Nal: 	Electrospray ionization mass spectrometry; Flavonoids; Fluconazole; Mass spectrometry; Ultra-performance liquid chromatography.	
Categoria do assunto: 	F Plantas e Produtos de Origem Vegetal
X Pesquisa, Tecnologia e Engenharia	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1159154/1/uplc-ms-esi-qtof-analysis-and-antifungal-activity-of-aqueous-extracts-of-spondias-tuberosa-2023.pdf	
Registro original: 	Embrapa Agroindústria Tropical (CNPAT)	
Exemplares: 	CNAT - (56-1) - UPC - AP - DD -  - SAN -  - DIS
CNPAT - (17144-1) - UPC - AP - DD -  -  -  - DIS
CNAT - (93-1) - UPC - AP - DD -  - SAN -  - DIS